Characteristics of junctional regions between Purkinje and ventricular muscle cells of canine ventricular subendocardium.
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چکیده
منابع مشابه
Characteristics of junctional regions between Purkinje and ventricular muscle cells of canine ventricular subendocardium.
The normal cardiac activation sequence requires propagation of the action potential from the subendocardial Purkinje network into the underlying ventricular muscle cells. This process occurs at specific junctional sites distributed over the endocardial surface of both ventricles. At these junctional sites, action potentials can be recorded from cells that appear to be interposed between the Pur...
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In the "Na lag hypothesis" of cardiac glycoside action, [Ca]i increases through sodium-calcium exchange following block of the sodium-calcium ATPase. This accumulation of [Ca]i has been suggested to be responsible for digitalis-induced delayed afterdepolarizations and arrhythmias. We used standard microelectrode techniques to study the effects of adriamycin, 10-200 fiM, on the canine Purkinje f...
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We have studied in vitro preparations of canine right and left papillary muscles to determine the excitation sequences of the Purkinje and ventricular cells, using both monopolar surface electrodes and intracellular microelectrodes. Our results show, for right papillary muscles, that the Purkinje layer covers the basal part of the muscle, and that activation from the right bundle branch propaga...
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In the "Na+ lag hypothesis" of cardiac glycoside action, [Ca++]i increases through sodium-calcium exchange following block of the sodium-calcium ATPase. This accumulation of [Ca++]i has been suggested to be responsible for digitalis-induced delayed after depolarizations and arrhythmias. We used standard microelectrode techniques to study the effects of adriamycin, 10-200 microM, on the canine P...
متن کاملElectrophysiological actions of disopyramide phosphate on canine ventricular muscle and purkinje fibers.
Disopyramide phosphate is a new antiarrhythmic drug that has been shown to possess significant antiarrhythmic effects in animals and man. In the present investigation, the effects of 2, 5, and 10 mug/ml of disopyramide phosphate were studied on the electrophysiological properties of canine Purkinje fibers and ventricular muscle superfused in vitro. Transmembrane action potentials were recorded ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1987
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.60.4.580